Psmc4^tm1Ryot
Targeted Allele Detail

Summary

• Symbol: Psmc4^tm1Ryot
• Name: proteasome (prosome, macropain) 26S subunit, ATPase, 4; targeted mutation 1, Ryosuke Takahashi
• MGI ID: MGI:6758663
• Gene: Psmc4 Location: Chr7:27741127-27749517 bp, - strand Genetic Position: Chr7, 16.11 cM
• Alliance: Psmc4^tm1Ryot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193770
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 7. An additional loxP site was inserted downstream of exon 10. (J:193770)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmc4 Mutation: 16 strains or lines available

References

• Original: J:193770 Tashiro Y, et al., Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem. 2012 Dec 14;287(51):42984-94
• All: 1 reference(s)