Brd7^tm1.1Ligy
Targeted Allele Detail

Summary

• Symbol: Brd7^tm1.1Ligy
• Name: bromodomain containing 7; targeted mutation 1.1, Guiyuan Li
• MGI ID: MGI:6758255
• Gene: Brd7 Location: Chr8:89057667-89088822 bp, - strand Genetic Position: Chr8, 43.07 cM, cytoband C4
• Alliance: Brd7^tm1.1Ligy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251649
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted an FRT-flanked neomycin resistance cassette with a 3' loxP site upstream of exon 3 and a second loxP site downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:251649)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brd7 Mutation: 32 strains or lines available

References

• Original: J:251649 Wang H, et al., Knockout of BRD7 results in impaired spermatogenesis and male infertility. Sci Rep. 2016 Feb 16;6:21776
• All: 1 reference(s)