Sptb^tm1Mnr
Targeted Allele Detail

Summary

• Symbol: Sptb^tm1Mnr
• Name: spectrin beta, erythrocytic; targeted mutation 1, Matthew N Rasband
• MGI ID: MGI:6758243
• Synonyms: Sptb^flox
• Gene: Sptb Location: Chr12:76627262-76757321 bp, - strand Genetic Position: Chr12, 33.73 cM
• Alliance: Sptb^tm1Mnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290600
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct flanked exon 2 with loxP sites and inserted an FRT-flanked neomycin resistance cassette. (J:290600)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sptb Mutation: 86 strains or lines available

References

• Original: J:290600 Liu CH, et al., Nodal beta spectrins are required to maintain Na(+) channel clustering and axon integrity. Elife. 2020 Feb 13;9:e52378
• All: 2 reference(s)