Vav2^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Vav2^tm1.2Geno
• Name: vav guanine nucleotide exchange factor 2; targeted mutation 1.2, Genoway
• MGI ID: MGI:6758213
• Synonyms: Vav2^L332A
• Gene: Vav2 Location: Chr2:27152116-27317045 bp, - strand Genetic Position: Chr2, 19.36 cM
• Alliance: Vav2^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290809
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting mutation inserted a lox511 site upstream of the endogenous exon 11 and an FRT-flanked neomycin resistance cassette inserted downstream of exon 11 followed by a floxed and inverted exon 11 with the amino acid substitution of leucine with alanine at position 332 (L332A) and a lox511 site. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. Cre-mediated recombination removed the exndogenous exon 11 and reverted the mutated exon 11. (J:290809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav2 Mutation: 48 strains or lines available

References

• Original: J:290809 Lorenzo-Martin LF, et al., Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor. Oncogene. 2020 Jul;39(28):5098-5111
• All: 2 reference(s)