Rragb^tm1.1Klg
Targeted Allele Detail

Summary

• Symbol: Rragb^tm1.1Klg
• Name: Ras-related GTP binding B; targeted mutation 1.1, Kun-Liang Guan
• MGI ID: MGI:6758211
• Synonyms: RagB fl
• Gene: Rragb Location: ChrX:151922977-151954939 bp, + strand Genetic Position: ChrX, 68.46 cM
• Alliance: Rragb^tm1.1Klg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305070
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 3 and an FRT-flanked neomycin resistance cassette with a 5' loxP site downstream of exon 3. Flp-mediated recombination removed the selection cassette. (J:305070)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rragb Mutation: 10 strains or lines available

References

• Original: J:305070 Kim YC, et al., Rag GTPases are cardioprotective by regulating lysosomal function. Nat Commun. 2014 Jul 1;5:4241
• All: 4 reference(s)