Col1a1^{tm1.1(CAG-Deptor)Mala}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1.1(CAG-Deptor)Mala}
• Name: collagen, type I, alpha 1; targeted mutation 1.1, Mathieu Laplante
• MGI ID: MGI:6758202
• Synonyms: Deptor^O/E
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1.1(CAG-Deptor)Mala} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307118
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Col1a1^{tm1.1(CAG-Deptor)Mala} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Deptor (MGI:2146322)

• Mutation details: RMCE inserted into the 3 UTR cassette acceptor a CAG promoter, floxed stop cassette, and the coding sequence. Cre-mediated recombination removed the floxed stop cassette. (J:307118)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

References

• Original: J:307118 Caron A, et al., Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity. Mol Metab. 2016 Feb;5(2):102-112
• All: 1 reference(s)