Prlh^em2Mgmj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prlh^em2Mgmj
• Name: prolactin releasing hormone; endonuclease-mediated mutation 2, Martin G Myers, Jr
• MGI ID: MGI:6757219
• Synonyms: Prlh^Flox
• Gene: Prlh Location: Chr1:90880830-90881749 bp, + strand Genetic Position: Chr1, 45.81 cM
• Alliance: Prlh^em2Mgmj page

Mutation origin

• Strain of Origin: (C57BL/6 x SJL)F2

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR/cas9 genome editing is used to insert LoxP sites upstream and downstream of Prlh exon 2. (J:309169)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prlh Mutation: 7 strains or lines available

References

• Original: J:309169 Cheng W, et al., NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity. Nat Commun. 2021 Aug 30;12(1):5175
• All: 1 reference(s)