Tlr7^em1Yph
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tlr7^em1Yph
• Name: toll-like receptor 7; endonuclease-mediated mutation 1, Yi-Ping Hsueh
• MGI ID: MGI:6756349
• Synonyms: Tlr7^t
• Gene: Tlr7 Location: ChrX:166087925-166113554 bp, - strand Genetic Position: ChrX, 78.31 cM, cytoband F5
• Alliance: Tlr7^em1Yph page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 genome editing is used to insert a Myc-HA dual tag into exon 3 before the stop codon as well as two loxP sites flanking exon 3. (J:309088)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr7 Mutation: 25 strains or lines available

References

• Original: J:309088 Chen CY, et al., Transcriptomic Analysis and C-Terminal Epitope Tagging Reveal Differential Processing and Signaling of Endogenous TLR3 and TLR7. Front Immunol. 2021;12:686060
• All: 2 reference(s)