Alox5tm1.1Lky
Targeted Allele Detail
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Symbol: |
Alox5tm1.1Lky |
Name: |
arachidonate 5-lipoxygenase; targeted mutation 1.1, Richard M Locksley |
MGI ID: |
MGI:6755140 |
Synonyms: |
Alox5fl, Alox5-flox |
Gene: |
Alox5 Location: Chr6:116387038-116438139 bp, - strand Genetic Position: Chr6, 53.79 cM
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Alliance: |
Alox5tm1.1Lky page
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Germline Transmission: |
Earliest citation of germline transmission:
J:288632
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Parent Cell Line: |
PRX-B6T (ES Cell)
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Strain of Origin: |
C57BL/6J
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: LoxP sites were inserted to flank the exon 6 of the Alox5 gene by homologous recombination in the ES cells. The neomycin resistance cassette was excised from chimera males by crossing to FLP1 expressing females.
(J:288632)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Alox5 Mutation: |
45 strains or lines available
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Original: |
J:288632 McGinty JW, et al., Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity. Immunity. 2020 Mar 17;52(3):528-541.e7 |
All: |
1 reference(s) |
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