Alox5^tm1.1Lky
Targeted Allele Detail

Summary

• Symbol: Alox5^tm1.1Lky
• Name: arachidonate 5-lipoxygenase; targeted mutation 1.1, Richard M Locksley
• MGI ID: MGI:6755140
• Synonyms: Alox5^fl, Alox5-flox
• Gene: Alox5 Location: Chr6:116387038-116438139 bp, - strand Genetic Position: Chr6, 53.79 cM
• Alliance: Alox5^tm1.1Lky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288632
• Parent Cell Line: PRX-B6T (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the exon 6 of the Alox5 gene by homologous recombination in the ES cells. The neomycin resistance cassette was excised from chimera males by crossing to FLP1 expressing females. (J:288632)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alox5 Mutation: 51 strains or lines available

References

• Original: J:288632 McGinty JW, et al., Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity. Immunity. 2020 Mar 17;52(3):528-541.e7
• All: 2 reference(s)