Mycn^tm1.2Mlit
Targeted Allele Detail

Summary

• Symbol: Mycn^tm1.2Mlit
• Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1.2, Jian Fei
• MGI ID: MGI:6755105
• Synonyms: N-myc^EGFP
• Gene: Mycn Location: Chr12:12986094-12991837 bp, - strand Genetic Position: Chr12, 6.14 cM, cytoband A3-B
• Alliance: Mycn^tm1.2Mlit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278529
• Parent Cell Line: PRX-129S6 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted tetracycline response element (TRE or tetO) and a loxP site into intron 1 and fused EGFP, FRT-flanked neomycin resistance cassette and an additional loxP site to the ATG translation initiation site in exon 2. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:278529)

Expression

In Mice Carrying this Mutation:

95 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mycn Mutation: 24 strains or lines available

References

• Original: J:278529 Ma M, et al., Dynamic expression of N-myc in mouse embryonic development using an enhanced green fluorescent protein reporter gene in the N-myc locus. Dev Growth Differ. 2014 Feb;56(2):152-60
• All: 1 reference(s)