Nlrp6^tm1Ics
Targeted Allele Detail

Summary

• Symbol: Nlrp6^tm1Ics
• Name: NLR family, pyrin domain containing 6; targeted mutation 1, Mouse Clinical Institute
• MGI ID: MGI:6740448
• Synonyms: Nlrp6-3xFlag-IRES-eGFP
• Gene: Nlrp6 Location: Chr7:140500815-140509105 bp, + strand Genetic Position: Chr7, 86.14 cM, cytoband F4
• Alliance: Nlrp6^tm1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267416
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Epitope tag, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a triple Flag epitope tag, IRES, and EGFP inserted into exon 8 upstream of the translation termination codon. (J:267416)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp6 Mutation: 46 strains or lines available

References

• Original: J:267416 Hara H, et al., The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 2018 Oct 26
• All: 2 reference(s)