Hic1^{tm2.1(cre/ERT2)Tmun}
Targeted Allele Detail

Summary

• Symbol: Hic1^{tm2.1(cre/ERT2)Tmun}
• Name: hypermethylated in cancer 1; targeted mutation 2.1, T Michael Underhill
• MGI ID: MGI:6740447
• Synonyms: Hic1^CreERT2
• Gene: Hic1 Location: Chr11:75055391-75060345 bp, - strand Genetic Position: Chr11, 45.76 cM
• Alliance: Hic1^{tm2.1(cre/ERT2)Tmun} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292396
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Hic1^{tm2.1(cre/ERT2)Tmun} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hic1 (MGI:1338010)

• Mutation details: A targeting vector introduced an IRES-CreERT2 cassette along with an FRT flanked PGKneo cassette into the 3' untranslated region of the Hic1 gene. Male chimeras were subsequently bred to Flippase-expressing mice to delete the PGK-neo cassette. (J:292396)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hic1 (mouse) Summary of all recombinase alleles driven by Hic1. Comparative matrix view of recombinase activities Alliance mouse Hic1 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hic1 Mutation: 36 strains or lines available

References

• Original: J:292396 Scott RW, et al., Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration. Cell Stem Cell. 2019 Dec 5;25(6):797-813.e9
• All: 7 reference(s)