Hic1^tm1.1Tmun
Targeted Allele Detail

Summary

• Symbol: Hic1^tm1.1Tmun
• Name: hypermethylated in cancer 1; targeted mutation 1.1, T Michael Underhill
• MGI ID: MGI:6740446
• Synonyms: Hic1^f
• Gene: Hic1 Location: Chr11:75055391-75060345 bp, - strand Genetic Position: Chr11, 45.76 cM
• Alliance: Hic1^tm1.1Tmun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292396
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129Sv/Pas

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector contained LoxP sites flanking the major coding exon 2 of Hic1, a PGK-neo cassette flanked by FRT sites distal to exon 2 and upstream of the 3' LoxP site. An IRES-NLS-LacZ cassette distal to the 3' LoxP site (downstream of exon 2) was added to enable the efficient identification of Hic1 deleted cells. The male chimeras were bred with female Flippase-expressing mice for deletion of the PGK-neo cassette. (J:292396)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hic1 Mutation: 36 strains or lines available

References

• Original: J:292396 Scott RW, et al., Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration. Cell Stem Cell. 2019 Dec 5;25(6):797-813.e9
• All: 5 reference(s)