Ube2i^tm2.2Adej
Targeted Allele Detail

Summary

• Symbol: Ube2i^tm2.2Adej
• Name: ubiquitin-conjugating enzyme E2I; targeted mutation 2.2, Anne Dejean
• MGI ID: MGI:6740166
• Gene: Ube2i Location: Chr17:25479482-25493856 bp, - strand Genetic Position: Chr17, 12.53 cM
• Alliance: Ube2i^tm2.2Adej page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252074
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct flanked exons 2 and 3 with loxP sites in the same orientation. Cre-mediated recombination removed the floxed neomycin selection cassette inserted into intron 3 as well as exons 2 and 3. (J:252074)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube2i Mutation: 22 strains or lines available

References

• Original: J:252074 Demarque MD, et al., Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice. Gastroenterology. 2011 Jan;140(1):286-96
• All: 3 reference(s)