Tcrb^tm4.1Itan
Targeted Allele Detail

Summary

• Symbol: Tcrb^tm4.1Itan
• Name: T cell receptor beta chain; targeted mutation 4.1, Ichiro Taniuchi
• MGI ID: MGI:6739846
• Synonyms: Ebeta^M3
• Gene: Tcrb Location: Chr6:40868230-41535305 bp, + strand Genetic Position: Chr6, cytoband A-C

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274549
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct inserted a floxed neomycin resistance cassette inserted downstream of the C beta2 exon and modified the first Runx1-binding site within the Ebeta enhancer (TGTGGTT to TGCCACA) and the third Runx1-binding site within the Ebeta enhancer (TGCCACA to TTGGACA). (J:274549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrb Mutation: 99 strains or lines available

References

• Original: J:274549 Seo W, et al., Distinct requirement of Runx complexes for TCRbeta enhancer activation at distinct developmental stages. Sci Rep. 2017 Feb 2;7:41351
• All: 1 reference(s)