Tcrbtm2.1Itan
Targeted Allele Detail
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Symbol: |
Tcrbtm2.1Itan |
Name: |
T cell receptor beta chain; targeted mutation 2.1, Ichiro Taniuchi |
MGI ID: |
MGI:6739844 |
Synonyms: |
EbetaM1 |
Gene: |
Tcrb Location: Chr6:40868230-41535305 bp, + strand Genetic Position: Chr6, cytoband A-C
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Germline Transmission: |
Earliest citation of germline transmission:
J:274549
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Not Applicable) |
Mutation: |
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Nucleotide substitutions
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Mutation details: The targeting construct inserted a floxed neomycin resistance cassette inserted downstream of the C beta2 exon and modified the first Runx1-binding site within the Ebeta enhancer (TGTGGTT to TGCCACA).
(J:274549)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tcrb Mutation: |
95 strains or lines available
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Original: |
J:274549 Seo W, et al., Distinct requirement of Runx complexes for TCRbeta enhancer activation at distinct developmental stages. Sci Rep. 2017 Feb 2;7:41351 |
All: |
1 reference(s) |
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