Ebi3^tm1.1Daav
Targeted Allele Detail

Summary

• Symbol: Ebi3^tm1.1Daav
• Name: Epstein-Barr virus induced gene 3; targeted mutation 1.1, Dario Vignali
• MGI ID: MGI:6739821
• Synonyms: Ebi3^L, Ebi3^Tom.L
• Gene: Ebi3 Location: Chr17:56259640-56264022 bp, + strand Genetic Position: Chr17, 29.08 cM
• Alliance: Ebi3^tm1.1Daav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254697
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced the translation initiation sequence with a tdTomato and 2A sequence and inserted a loxP site into intron 1 and an FRT-flanked neomycin resistance cassette, loxP site, and Thy1.1 cDNA into intron 5. Flp-mediated mutation removed the selection cassette. (J:254697)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ebi3 Mutation: 13 strains or lines available

References

• Original: J:254697 Turnis ME, et al., Interleukin-35 Limits Anti-Tumor Immunity. Immunity. 2016 Feb 16;44(2):316-29
• All: 7 reference(s)