Pdgfrbtm1.2(flpo)Leol
Targeted Allele Detail
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Symbol: |
Pdgfrbtm1.2(flpo)Leol |
Name: |
platelet derived growth factor receptor, beta polypeptide; targeted mutation 1.2, Lorin E Olson |
MGI ID: |
MGI:6731087 |
Synonyms: |
bRdeltaFlp, PdgfrbdetalFlp |
Gene: |
Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
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Alliance: |
Pdgfrbtm1.2(flpo)Leol page
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Germline Transmission: |
Earliest citation of germline transmission:
J:306160
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout, Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Pdgfrbtm1.2(flpo)Leol expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Pdgfrb (MGI:97531) |
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Mutation details: The targeting cassette consisting of a SA.lox.PDGFRb.lox-Flpo-attB-Neo-attP cassette replaced the exons 2-4 of the endogenous Pdgfrb gene. The PDGFRb is a mouse Pdgfrb gene cDNA. PhiC31 integrase removed the attB-Neo-attP cassette. Cre-mediated recombination removed lox.PDGFRb.lox cassette from Pdgfrbtm1.1(flpo)Leol to enable the expression of the flpo recombinase. This is a nock-in-nock-out null allele.
(J:306160)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Pdgfrb
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pdgfrb Mutation: |
84 strains or lines available
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Original: |
J:306160 Sun C, et al., Mosaic Mutant Analysis Identifies PDGFRalpha/PDGFRbeta as Negative Regulators of Adipogenesis. Cell Stem Cell. 2020 May 7;26(5):707-721.e5 |
All: |
1 reference(s) |
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