Irf3^tm2.2Ttg
Targeted Allele Detail

Summary

• Symbol: Irf3^tm2.2Ttg
• Name: interferon regulatory factor 3; targeted mutation 2.2, Tadatsugu Taniguchi
• MGI ID: MGI:6730127
• Gene: Irf3 Location: Chr7:44647072-44652272 bp, + strand Genetic Position: Chr7, 29.07 cM, cytoband B2
• Alliance: Irf3^tm2.2Ttg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267354
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted an FRT-flanked neomycin resistance cassette with a 5' UTR upstream of exon 2 and an additional loxp site downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. (J:267354)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf3 Mutation: 35 strains or lines available

References

• Original: J:267354 Yanai H, et al., Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Proc Natl Acad Sci U S A. 2018 May 15;115(20):5253-5258
• All: 1 reference(s)