Otub1^tm1Ama
Targeted Allele Detail

Summary

• Symbol: Otub1^tm1Ama
• Name: OTU domain, ubiquitin aldehyde binding 1; targeted mutation 1, Averil Ma
• MGI ID: MGI:6730110
• Gene: Otub1 Location: Chr19:7175571-7183649 bp, - strand Genetic Position: Chr19, 5.27 cM
• Alliance: Otub1^tm1Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267520
• Parent Cell Line: PRX-B6T (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The targeting construct replaced exons 4 through 7 with a floxed neomycin resistance cassette. (J:267520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otub1 Mutation: 26 strains or lines available

References

• Original: J:267520 Pasupala N, et al., OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination. J Biol Chem. 2018 Nov 23;293(47):18285-18295
• All: 1 reference(s)