Ebf2^tm1.1Seale
Targeted Allele Detail

Summary

• Symbol: Ebf2^tm1.1Seale
• Name: early B cell factor 2; targeted mutation 1.1, Patrick Seale
• MGI ID: MGI:6730109
• Synonyms: Ebf2^fl
• Gene: Ebf2 Location: Chr14:67470741-67668367 bp, + strand Genetic Position: Chr14, 34.63 cM, cytoband D-E1
• Alliance: Ebf2^tm1.1Seale page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242983
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 3 and a FRT-flanked neomycin selection cassette, followed by a second loxP site, downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:242983)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ebf2 Mutation: 32 strains or lines available

References

• Original: J:242983 Shapira SN, et al., EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex. Genes Dev. 2017 Apr 01;31(7):660-673
• All: 1 reference(s)