Slc27a4^em1Akih
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc27a4^em1Akih
• Name: solute carrier family 27 (fatty acid transporter), member 4; endonuclease-mediated mutation 1, Akio Kihara
• MGI ID: MGI:6730083
• Gene: Slc27a4 Location: Chr2:29692646-29707534 bp, + strand Genetic Position: Chr2, 20.64 cM, cytoband B
• Alliance: Slc27a4^em1Akih page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 3 deleted a single base pair. This allele is predicted to generate a protein with the N-terminal 66 amino acids of wild-type (WT) protein (643amino acids), unrelated 42 amino acids due to a frameshift, and premature termination. (J:287986)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc27a4 Mutation: 33 strains or lines available

References

• Original: J:287986 Yamamoto H, et al., Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid omega-O-acylceramide. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2914-2922
• All: 2 reference(s)