Myb^tm1.1Husm
Targeted Allele Detail

Summary

• Symbol: Myb^tm1.1Husm
• Name: Myb proto-oncogene, transcription factor; targeted mutation 1.1, Hamamatsu University School of Medicine
• MGI ID: MGI:6729924
• Synonyms: Myb^{tm1.1(T572A)Husm}
• Gene: Myb Location: Chr10:21000834-21036883 bp, - strand Genetic Position: Chr10, 9.75 cM
• Alliance: Myb^tm1.1Husm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296408
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct replaced exon 14 with one coding for the amino acid substitution of threonine with alanine at position 572 (T572A). Cre-mediated recombination removed the neomycin resistance cassette inserted downstream of the modified exon. (J:296408)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myb Mutation: 56 strains or lines available

References

• Original: J:296408 Kitagawa K, et al., Substitution of Thr572 to Ala in mouse c-Myb attenuates progression of early erythroid differentiation. Sci Rep. 2020 Sep 1;10(1):14381
• All: 1 reference(s)