Del(3Sprr2a1-Sprr2a3)1Lvh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(3Sprr2a1-Sprr2a3)1Lvh
• Name: deletion, chr 3, Lora Hooper
• MGI ID: MGI:6729717
• Synonyms: Sprr2a^-
• Gene: Del(3Sprr2a1-Sprr2a3)1Lvh Location: unknown Genetic Position: Chr3, Syntenic

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: An 81 kb genomic segment encoding Sprr2a1, Sprr2a2, and Sprr2a3 is deleted using CRISPR/Cas9 methodologies (gRNAs: GTGTAGAAAAAAGGATCGGTGGG (upstream), and ATTATCAGCGGTGTACTGCCAGG (downstream); GRCm38.p6: 92,210,732-92,291,813). (J:314159)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(3Sprr2a1-Sprr2a3)1Lvh Mutation: 1 strain or line available

References

• Original: J:314159 Hu Z, et al., Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection. Science. 2021 Nov 5;374(6568):eabe6723
• All: 1 reference(s)