Pde11a^tm1Pfi
Targeted Allele Detail

Summary

• Symbol: Pde11a^tm1Pfi
• Name: phosphodiesterase 11A; targeted mutation 1, Pfizer, Ltd
• MGI ID: MGI:6728811
• Gene: Pde11a Location: Chr2:75819485-76169118 bp, - strand Genetic Position: Chr2, 44.8 cM
• Alliance: Pde11a^tm1Pfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307334
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced the endogenous gene with a modified human gene in which a lacZ reporter gene and neomycin resistance cassette replaced 16 bp in exon 12, which encodes the catalytic domain disrupting it. (J:307334)

Expression

In Mice Carrying this Mutation:

27 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde11a Mutation: 48 strains or lines available

References

• Original: J:307334 Wayman C, et al., Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology. Int J Impot Res. 2005 May-Jun;17(3):216-23
• All: 2 reference(s)