Lpin1^tm1.1Rchr
Targeted Allele Detail

Summary

• Symbol: Lpin1^tm1.1Rchr
• Name: lipin 1; targeted mutation 1.1, Roman Chrast
• MGI ID: MGI:6728792
• Synonyms: Lpin1 KO
• Gene: Lpin1 Location: Chr12:16585670-16696967 bp, - strand Genetic Position: Chr12, 7.9 cM
• Alliance: Lpin1^tm1.1Rchr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308207
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination in the germline resulted in the deletion of exon 2 and the selection cassette. (J:137213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpin1 Mutation: 56 strains or lines available

References

• Original: J:308207 Chandran S, et al., Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization. Front Immunol. 2020;11:787
• All: 2 reference(s)