Ptgs1^tm1Sage
Targeted Allele Detail

Summary

• Symbol: Ptgs1^tm1Sage
• Name: prostaglandin-endoperoxide synthase 1; targeted mutation 1, Sigma Aldrich, Sigma Advanced Genetic Engineering - SAGE Labs
• MGI ID: MGI:6728545
• Synonyms: Cox1^fl
• Gene: Ptgs1 Location: Chr2:36120438-36142284 bp, + strand Genetic Position: Chr2, 24.19 cM
• Alliance: Ptgs1^tm1Sage page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305775
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The coding sequence was floxed. (J:305775)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs1 Mutation: 45 strains or lines available

References

• Original: J:305775 Klawonn AM, et al., Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons. Immunity. 2021 Feb 9;54(2):225-234.e6
• All: 1 reference(s)