Fasn^em1Sjes
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fasn^em1Sjes
• Name: fatty acid synthase; endonuclease-mediated mutation 1, Sebastian Jessberger
• MGI ID: MGI:6728543
• Synonyms: Fasn-R1812W
• Gene: Fasn Location: Chr11:120696672-120715373 bp, - strand Genetic Position: Chr11, 84.56 cM
• Alliance: Fasn^em1Sjes page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Zinc finger endonuclease-targeting altered cgg to TgG introducing the amino acid substitution of arginine with tryptophan at position 1812 (R1812W). (J:306159)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fasn Mutation: 89 strains or lines available

References

• Original: J:306159 Bowers M, et al., FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits. Cell Stem Cell. 2020 Jul 2;27(1):98-109.e11
• All: 2 reference(s)