Cxcl12^tm1.1Bdr
Targeted Allele Detail

Summary

• Symbol: Cxcl12^tm1.1Bdr
• Name: C-X-C motif chemokine ligand 12; targeted mutation 1, Michel Bader
• MGI ID: MGI:6728532
• Synonyms: CXCL12^delta
• Gene: Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
• Alliance: Cxcl12^tm1.1Bdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308155
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct introduced an FRT-flanked neomycin resistance cassette with a 5' loxP site upstream of exon 1 and a second loxP site downstream of exon 1. Cre-mediated recombination removed the selection and exon 1. (J:308155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl12 Mutation: 24 strains or lines available

References

• Original: J:308155 Muhlstedt S, et al., Cardiomyocyte-derived CXCL12 is not involved in cardiogenesis but plays a crucial role in myocardial infarction. J Mol Med (Berl). 2016 Sep;94(9):1005-14
• All: 1 reference(s)