Adar^em3Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adar^em3Osb
• Name: adenosine deaminase, RNA-specific; endonuclease-mediated mutation 3, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6728521
• Synonyms: Adar1 p110^- line 15
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^em3Osb page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s), Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted the constitutive promoter, exon 1B, and a possible alternative exon 1C required for the transcription of the p110 isoform (chr3: 89714049-89715628; build 38). Expression of isoform p150 is not altered. (J:306164)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 83 strains or lines available

References

• Original: J:306164 Kim JI, et al., RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain. PLoS Genet. 2021 May;17(5):e1009516
• All: 1 reference(s)