Adar^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adar^em1Osb
• Name: adenosine deaminase, RNA-specific; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6728505
• Synonyms: Adar1^E861A
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^em1Osb page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting modified the coding sequence to induce the amino acid substitution of glutamic acid with alanine at position 861 (E861A). (J:288804)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 83 strains or lines available

References

• Original: J:288804 Costa Cruz PH, et al., A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing. RNA. 2020 Apr;26(4):454-469
• All: 5 reference(s)