Aifm1^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Aifm1^tm1.2Geno
• Name: apoptosis-inducing factor, mitochondrion-associated 1; targeted mutation 1.2, Genoway
• MGI ID: MGI:6728504
• Gene: Aifm1 Location: ChrX:47563821-47602440 bp, - strand Genetic Position: ChrX, 25.68 cM, cytoband A6
• Alliance: Aifm1^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306165
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct flanked exon 11 with loxP sites. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted into intron 11. Cre-mediated recombination removed exon 11. (J:306165)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aifm1 Mutation: 9 strains or lines available

References

• Original: J:306165 Delavallee L, et al., Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus. Mol Metab. 2020 Oct;40:101027
• All: 1 reference(s)