Arhgap10^em3Kyad
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arhgap10^em3Kyad
• Name: Rho GTPase activating protein 10; endonuclease-mediated mutation 3, Kiyofumi Yamada
• MGI ID: MGI:6728050
• Synonyms: Arhgap10^S490P
• Gene: Arhgap10 Location: Chr8:77976995-78244582 bp, - strand Genetic Position: Chr8, 36.6 cM, cytoband C2
• Alliance: Arhgap10^em3Kyad page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: TALEN-targeting altered the sequence (TCC to CCT) to produce the amino acid substitution of serine with proline at position 490 (S490P). This mutations are present in a patient with schizophrenia. (J:305033)

Expression

In Mice Carrying this Mutation:

32 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgap10 Mutation: 53 strains or lines available

References

• Original: J:305033 Sekiguchi M, et al., ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Transl Psychiatry. 2020 Jul 22;10(1):247
• All: 2 reference(s)