Cdkn2atm2.1(cre/ERT2)Dvb
Targeted Allele Detail
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Symbol: |
Cdkn2atm2.1(cre/ERT2)Dvb |
Name: |
cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Dmitry V Bulavin |
MGI ID: |
MGI:6727120 |
Synonyms: |
p16-CreERt2 |
Gene: |
Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
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Alliance: |
Cdkn2atm2.1(cre/ERT2)Dvb page
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Germline Transmission: |
Earliest citation of germline transmission:
J:296551
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Inducible, Recombinase, Reporter) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Cdkn2atm2.1(cre/ERT2)Dvb expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Cdkn2a (MGI:104738) |
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Mutation details: An F2A-Cre/ERT2-T2A-TK-E2A-tdTomato cassette was introduced at the end of the last exon of the Cdkn2a (p16Ink4) gene by homologous recombination in the ES cells. The Frt-loxed
Neo cassette was removed by crossing with FLP deleter.
(J:296551)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cdkn2a
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cdkn2a Mutation: |
62 strains or lines available
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Original: |
J:296551 Grosse L, et al., Defined p16(High) Senescent Cell Types Are Indispensable for Mouse Healthspan. Cell Metab. 2020 Jul 7;32(1):87-99.e6 |
All: |
1 reference(s) |
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