Cdkn2atm1.1(cre)Dvb
Targeted Allele Detail
|
Symbol: |
Cdkn2atm1.1(cre)Dvb |
Name: |
cyclin dependent kinase inhibitor 2A; targeted mutation 1.1, Dmitry V Bulavin |
MGI ID: |
MGI:6727119 |
Synonyms: |
p16-Cre |
Gene: |
Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
|
Alliance: |
Cdkn2atm1.1(cre)Dvb page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:296551
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
C57BL/6
|
|
Allele Type: |
|
Targeted (Recombinase, Reporter) |
Mutation: |
|
Insertion
|
|
|
Cdkn2atm1.1(cre)Dvb expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Cdkn2a (MGI:104738) |
|
|
|
|
Mutation details: A F2A-Cre-T2A-TK-E2A-tdTomato cassette was introduced at the end of the last exon of the Cdkn2a (p16Ink4) gene by homologous recombination in the ES cells. The Frt-loxed
Neo cassette was removed by crossing with FLP deleter.
(J:296551)
|
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
Cdkn2a
(mouse)
|
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Cdkn2a Mutation: |
62 strains or lines available
|
|
Original: |
J:296551 Grosse L, et al., Defined p16(High) Senescent Cell Types Are Indispensable for Mouse Healthspan. Cell Metab. 2020 Jul 7;32(1):87-99.e6 |
All: |
1 reference(s) |
|