Cplx1^tm1.1Bros
Targeted Allele Detail

Summary

• Symbol: Cplx1^tm1.1Bros
• Name: complexin 1; targeted mutation 1.1, Nils Brose
• MGI ID: MGI:6726555
• Synonyms: Cplx1^flox
• Gene: Cplx1 Location: Chr5:108666420-108697890 bp, - strand Genetic Position: Chr5, 53.17 cM
• Alliance: Cplx1^tm1.1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298868
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/Ola

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: By homologous recombination in embryonic stem cells (ES), two loxP sites and a neo cassette were introduced flanking the exon 2, one at 212 bp upstream of exon 2 and another at 53 bp downstream of the exon 2 after the Neomycin resistance cassette, which was flanked by two FRT sites. The neo cassette was removed by FLIP-recombination. (J:298868)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cplx1 Mutation: 11 strains or lines available

References

• Original: J:298868 Lopez-Murcia FJ, et al., Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release. Cell Rep. 2019 Mar 5;26(10):2521-2530.e5
• All: 1 reference(s)