Tcf20^em1Jwji
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tcf20^em1Jwji
• Name: transcription factor 20; endonuclease-mediated mutation 1, Jianwei Jiao
• MGI ID: MGI:6726263
• Gene: Tcf20 Location: Chr15:82692637-82872073 bp, - strand Genetic Position: Chr15, 38.73 cM, cytoband E
• Alliance: Tcf20^em1Jwji page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting the two ends of exon 2 deleted exon 2 (approximately 5 kb of the gene, deleting the majority of the coding sequence). Western blot and RT-qPCR confirmed absence of protein and transcript. (J:306854)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf20 Mutation: 90 strains or lines available

References

• Original: J:306854 Feng C, et al., TCF20 dysfunction leads to cortical neurogenesis defects and autistic-like behaviors in mice. EMBO Rep. 2020 Aug 5;21(8):e49239
• All: 1 reference(s)