Cdkn2atm1(cre/ERT2)Mkt
Targeted Allele Detail
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Symbol: |
Cdkn2atm1(cre/ERT2)Mkt |
Name: |
cyclin dependent kinase inhibitor 2A; targeted mutation 1, Makoto Nakanishi |
MGI ID: |
MGI:6726124 |
Synonyms: |
p16-CreERT2, p16Ink4a-CreERT2neo |
Gene: |
Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
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Alliance: |
Cdkn2atm1(cre/ERT2)Mkt page
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Germline Transmission: |
Earliest citation of germline transmission:
J:300221
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Cdkn2atm1(cre/ERT2)Mkt expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Cdkn2a (MGI:104738) |
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Mutation details: The exon 1 alpha of the Cdkn2a gene was replaced with a translation start site, a CreERT2 expression cassette and a neo cassette. The retained neo-resistant gene markedly resulted in higher labeling efficacy at this locus presumably due to the fact that a retained neo-resistant cassette can act as a local enhancer to augment reporter expression without compromising tissue reporter fidelity.
(J:300221)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cdkn2a
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cdkn2a Mutation: |
62 strains or lines available
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Original: |
J:300221 Omori S, et al., Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16(high) Cells In Vivo. Cell Metab. 2020 Nov 3;32(5):814-828.e6 |
All: |
1 reference(s) |
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