Nox3tm1.1(cre)Kobio
Targeted Allele Detail
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Symbol: |
Nox3tm1.1(cre)Kobio |
Name: |
NADPH oxidase 3; targeted mutation 1.1, Takehiko Ueyama |
MGI ID: |
MGI:6725847 |
Synonyms: |
Nox3-Cre KI |
Gene: |
Nox3 Location: Chr17:3685515-3746536 bp, - strand Genetic Position: Chr17, 2.05 cM
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Alliance: |
Nox3tm1.1(cre)Kobio page
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Germline Transmission: |
Earliest citation of germline transmission:
J:306032
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6J
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Allele Type: |
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Targeted (Null/knockout, Recombinase) |
Mutation: |
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Insertion
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Nox3tm1.1(cre)Kobio expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: By homologous recombination in ES cells, cre-SV40 expression cassette and the PGK promoter (PGK) followed by a neomycin-resistant gene (Neo) flanked by FRT was inserted at the ATG site of exon 1 of Nox3 on chromosome 17. The founder mice were crossed with CAG-FLP mice to remove the Neo cassette. This is a null allele.
(J:306032)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Nox3
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nox3 Mutation: |
38 strains or lines available
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Original: |
J:306032 Mohri H, et al., Nox3-Derived Superoxide in Cochleae Induces Sensorineural Hearing Loss. J Neurosci. 2021 May 26;41(21):4716-4731 |
All: |
1 reference(s) |
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