Slamf1^em2Vei
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slamf1^em2Vei
• Name: signaling lymphocytic activation molecule family member 1; endonuclease-mediated mutation 2, Andre Veillette
• MGI ID: MGI:6725830
• Synonyms: Slamf1^em2Av
• Gene: Slamf1 Location: Chr1:171594700-171628752 bp, + strand Genetic Position: Chr1, 79.54 cM
• Alliance: Slamf1^em2Vei page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas mediated recombination using the guide RNA sequence 5'-GCCTGTTCCCGAGGATCTTC-3' created a 7 bp deletion in exon 2 creating a frameshift mutation. (J:307792)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slamf1 Mutation: 30 strains or lines available

References

• Original: J:307792 Zhong MC, et al., SLAM family receptors control pro-survival effectors in germinal center B cells to promote humoral immunity. J Exp Med. 2021 Mar 1;218(3)
• All: 1 reference(s)