Adra1a^em1Pcs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adra1a^em1Pcs
• Name: adrenergic receptor, alpha 1a; endonuclease-mediated mutation 1, Paul C Simpson
• MGI ID: MGI:6725091
• Synonyms: GqKI
• Gene: Adra1a Location: Chr14:66872700-67008617 bp, + strand Genetic Position: Chr14, 34.6 cM, cytoband D1
• Alliance: Adra1a^em1Pcs page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology was used to generate a 6 amino acid substitution at amino acids 228-233, DSEQVT to CCPGCC, in the third intracellular loop. This change disrupts Gq signaling. (J:307747)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adra1a Mutation: 30 strains or lines available

References

• Original: J:307747 Myagmar BE, et al., Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist. Circ Res. 2019 Sep 13;125(7):699-706
• All: 1 reference(s)