Cdk6^tm1.1Mrc
Targeted Allele Detail

Summary

• Symbol: Cdk6^tm1.1Mrc
• Name: cyclin dependent kinase 6; targeted mutation 1.1, Mario R Capecchi
• MGI ID: MGI:6724055
• Synonyms: Cdk6^T2A-td-sfGFP
• Gene: Cdk6 Location: Chr5:3391485-3581008 bp, + strand Genetic Position: Chr5, 2.04 cM, cytoband A2-A3
• Alliance: Cdk6^tm1.1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286603
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct contains a T2A-tandem dimer (td)-sfGFP (superfolder green fluorescent protein)-FRT-Neo-FRT cassette, which replaces the stop codon just before the 3' untranslated region. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:286603)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdk6 Mutation: 39 strains or lines available

References

• Original: J:286603 Nam HS, et al., Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life. Neural Dev. 2020 Mar 17;15(1):3
• All: 1 reference(s)