Wasf2^tm1Kas
Targeted Allele Detail

Summary

• Symbol: Wasf2^tm1Kas
• Name: WASP family, member 2; targeted mutation 1, Katherine A Siminovitch
• MGI ID: MGI:6723826
• Synonyms: Wave2^fl
• Gene: Wasf2 Location: Chr4:132857843-132927067 bp, + strand Genetic Position: Chr4, 66.22 cM
• Alliance: Wasf2^tm1Kas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The targeting construct floxed exon 2 and 3 and inserted a neomycin resistance cassette. (J:306989)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wasf2 Mutation: 122 strains or lines available

References

• Original: J:306989 Liu M, et al., WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity. Science. 2021 Mar 26;371(6536)
• All: 1 reference(s)