Lats1^tm1Bcgen
Targeted Allele Detail

Summary

• Symbol: Lats1^tm1Bcgen
• Name: large tumor suppressor; targeted mutation 1, Biocytogen LLC
• MGI ID: MGI:6723820
• Gene: Lats1 Location: Chr10:7556978-7592224 bp, + strand Genetic Position: Chr10, 2.29 cM, cytoband A1
• Alliance: Lats1^tm1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• A null allele was generated. (J:306991)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lats1 Mutation: 54 strains or lines available

References

• Original: J:306991 Zhou R, et al., The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration. PLoS Biol. 2021 Feb;19(2):e3001122
• All: 1 reference(s)