Pfkfb3^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pfkfb3^em1Nju
• Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6723804
• Gene: Pfkfb3 Location: Chr2:11476241-11558882 bp, - strand Genetic Position: Chr2, 8.73 cM
• Alliance: Pfkfb3^em1Nju page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 2 deleted 73 bp. (J:307014)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pfkfb3 Mutation: 38 strains or lines available

References

• Original: J:307014 Jiang H, et al., PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense. J Immunol. 2016 Oct 1;197(7):2880-90
• All: 1 reference(s)