Hoxa11^{em1(cre/ERT2)Dmwe}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hoxa11^{em1(cre/ERT2)Dmwe}
• Name: homeobox A11; endonuclease-mediated mutation 1, Deneen M Wellik
• MGI ID: MGI:6723802
• Synonyms: Hoxa11-CreER^T2
• Gene: Hoxa11 Location: Chr6:52219086-52222784 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa11^{em1(cre/ERT2)Dmwe} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Hoxa11^{em1(cre/ERT2)Dmwe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxa11 (MGI:96172)

• Mutation details: CRISPR/Cas9-targeting replaced most of the exon 1 after the translation initiation codon with a Cre/ERT2 and rabbit -globin poly(A) expression cassette. This is a knock-in, knock-out allele. (J:287761)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxa11 (mouse) Summary of all recombinase alleles driven by Hoxa11. Comparative matrix view of recombinase activities Alliance mouse Hoxa11 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa11 Mutation: 11 strains or lines available

References

• Original: J:287761 Pineault KM, et al., Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life. Nat Commun. 2019 Jul 18;10(1):3168
• All: 2 reference(s)