Naa12^em1Gjl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Naa12^em1Gjl
• Name: N(alpha)-acetyltransferase 12, NatA catalytic subunit; endonuclease-mediated mutation 1, Gholson J Lyon
• MGI ID: MGI:6723741
• Gene: Naa12 Location: Chr18:80250041-80255949 bp, + strand Genetic Position: Chr18, 53.34 cM
• Alliance: Naa12^em1Gjl page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1 x C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 endonuclease-mediated genome editing is used to create a 95 base pairs (131-225, Gm16286, UniProt Q9CQX6 ) deletion. The mutation creates a frameshift resulting in a termination codon at amino acid 67. (J:308825)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Naa12 Mutation: 8 strains or lines available

References

• Original: J:308825 Kweon HY, et al., Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway. Elife. 2021 Aug 6;10:e65952
• All: 1 reference(s)