Tg(Myh6-CASP3)#Gcon
Transgene Detail

Summary

• Symbol: Tg(Myh6-CASP3)#Gcon
• Name: transgene insertion, Gianluigi Condorelli
• MGI ID: MGI:6721422
• Transgene: Tg(Myh6-CASP3)#Gcon Location: unknown
• Alliance: Tg(Myh6-CASP3)#Gcon page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-CASP3)#Gcon expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CASP3 (836)

  Casp3

  (MGI:107739)

  mouse promoter, human cDNA

• Mutation details: This transgene insert contains the following elements: mouse cardiac muscle myosin heavy polypeptide 6 alpha promoter sequence to drive the heart-specific expression of the human caspase 3 cDNA, and SV40 intron and poly(A) signal sequences. (J:134061)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:134061 Condorelli G, et al., Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9977-82
• All: 1 reference(s)