Hprt1^{tm1(CAG-mCherry*)Koba}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(CAG-mCherry*)Koba}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Kazuto Kobayashi
• MGI ID: MGI:6721039
• Synonyms: Hprt-RED, Hprt^{tm1(CAG-mcherry-NLS)Koba}
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(CAG-mCherry*)Koba} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240352
• Parent Cell Line: BPES (ES Cell)
• Strain of Origin: (129-Hprt1^b-m3 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the intron 1, a CAG promoter driving ubiquitous expression of an mCherry reporter gene with a nuclear localization sequence, and a wild-type exon 1. (J:240352)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:240352 Kobayashi S, et al., Live imaging of X chromosome reactivation dynamics in early mouse development can discriminate naive from primed pluripotent stem cells. Development. 2016 Aug 15;143(16):2958-64
• All: 2 reference(s)