Il21^em1Ygch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il21^em1Ygch
• Name: interleukin 21; endonuclease-mediated mutation 1, Yi-Guang Chen
• MGI ID: MGI:6720990
• Synonyms: IL-21 KO
• Gene: Il21 Location: Chr3:37276908-37286785 bp, - strand Genetic Position: Chr3, 18.36 cM, cytoband B
• Alliance: Il21^em1Ygch page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Zinc finger nuclease genome editing is used to target exon 1, creating a 1 bp deletion and early termination. This is line 39. (J:307072)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il21 Mutation: 43 strains or lines available

References

• Original: J:307072 Allred MG, et al., Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice. Int J Mol Sci. 2021 Apr 5;22(7)
• All: 2 reference(s)